Slide backgroundpharmaceutical manufacturing companies
Slide background

Innovates to Serve People

Slide background

WHO-GMP Certified Facilities

Vardenafil Tablets

Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. The cGMP in turn triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection. The tissue concentration of cGMP is regulated by both the rates of synthesis and degradation via phosphodiesterases (PDEs). The most abundant PDE in the human corpus cavernosum is the cGMP-specific PDE5; therefore, the inhibition of PDE5 enhances erectile function by increasing the amount of cGMP. Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 has no effect in the absence of sexual stimulation.

In vitro studies have shown that vardenafil is a selective inhibitor of PDE5. The inhibitory effect of vardenafil is more selective on PDE5 than for other known phosphodiesterases (>15-fold relative to PDE6, >130-fold relative to PDE1, >300-fold relative to PDE11, and >1,000-fold relative to PDE2, 3, 4, 7, 8, 9, and 10).

INDICATION

Vardenafil is indicated for the treatment of erectile dysfunction.

 

WHO - GMP

Good Manufacturing Practice (GMP) is a system for ensuring that products are consistently produced and controlled according to quality standards. It is designed to minimize the risks involved in

Manufacturing

Maxtreme Pharma is a GMP certified pharmaceutical company. The company manufactures and sells pharmaceutical products. The company produces a wide range of Human Grade

Quality Control

We are committed to produce our products as per international BP/USP standards. Quality is the most important aspect at Maxtreme Pharma (with our joint ventures). We always keep

Contact Us

If you have any questions contact us by filling out this web form.

Enquiry Form

Your Name (required)

Your Email (required)

Phone Number

Country

Your Message